|
Anhedonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
This neurotransmitter plasticity is activity-dependent, as was revealed by chemogenetic manipulation of the central amygdala, a stress-sensitive nucleus that forms a major input to the DR. Activation of amygdalar corticotropin releasing hormone (CRH)+ neurons abolished the increase in DRv TPH2+ neurons and ameliorated stress-induced anhedonia in susceptible rats.
|
31792153 |
2020 |
|
Attention deficit hyperactivity disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
<b>Introduction:</b> Studies have documented both executive functions (EF) impairment in children with Attention Deficit / Hyperactivity Disorders (ADHD) and Theory of Mind (ToM), yielding mixed results, possibly because of a variety of tasks used, all requiring different levels of language skills.<b>Aim:</b> To investigate the relationship between ToM and EF with non-language-based tasks.<b>Methods:</b> Thirty ADHD (7-9 years old) were compared to thirty controls (age and IQ matched).
|
31661370 |
2020 |
|
Anxiety
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Priming with Ucn1 increased tph2 mRNA expression selectively within the anxiety-related dorsal part of the DR (DRD) and decreased social interaction (SI) time, a measure of anxiety-related defensive behavioral responses in rodents.
|
31415826 |
2020 |
|
Anxiety Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Priming with Ucn1 increased tph2 mRNA expression selectively within the anxiety-related dorsal part of the DR (DRD) and decreased social interaction (SI) time, a measure of anxiety-related defensive behavioral responses in rodents.
|
31415826 |
2020 |
|
Mental disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Evidence suggests that mice deficient in Tph2, the rate-limiting enzyme for brain serotonin synthesis, display disruptions in behavioral phenotypes relevant to stress-related psychiatric disorders.
|
31319134 |
2019 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Evidence suggests that mice deficient in Tph2, the rate-limiting enzyme for brain serotonin synthesis, display disruptions in behavioral phenotypes relevant to stress-related psychiatric disorders.
|
31319134 |
2019 |
|
Post-Traumatic Stress Disorder
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The SNPs rs6295 (HTR1A), rs11178997 and rs1386494 (TPH2) were investigated for their association with PTSD and comorbid psychopathology.
|
31291234 |
2019 |
|
Autism Spectrum Disorders
|
0.060 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that certain missense variants in the C. elegans orthologs of human CACNA1D, CHD7, CHD8, CUL3, DLG4, GLRA2, NAA15, PTEN, SYNGAP1 and TPH2 impact neurodevelopment and movement functions, elevating these genes as candidates for future study into ASD.
|
31220273 |
2019 |
|
Mental disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
This dual role of TPH2 should be taken into consideration during therapy of psychiatric disorders.
|
31216212 |
2019 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This dual role of TPH2 should be taken into consideration during therapy of psychiatric disorders.
|
31216212 |
2019 |
|
Mixed anxiety and depressive disorder
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We show the dual role of the TPH2 activity: both deficit and excess of the TPH2 activity cause significant behavioral disturbances in animal models of depression, anxiety, aggression, obsessive-compulsive disorders, schizophrenia, and catalepsy.
|
31216212 |
2019 |
|
Catalepsy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We show the dual role of the TPH2 activity: both deficit and excess of the TPH2 activity cause significant behavioral disturbances in animal models of depression, anxiety, aggression, obsessive-compulsive disorders, schizophrenia, and catalepsy.
|
31216212 |
2019 |
|
Fetal Growth Retardation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Although there was no significant change in TPH1 mRNA, the mRNA of TPH2 and SLC6A4 was significantly decreased in FGR placentae (p < 0.05), while 5-HT receptor mRNA was significantly increased in FGR compared with control (p < 0.01).
|
31176514 |
2019 |
|
Parkinson Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Together with increased tryptophan hydroxylase 2 mRNA levels in the raphe nuclei and an elevated serotonin receptor 1b expression in the PFC, these findings point to compensatory mechanisms within the serotonergic system to overcome the reduced neuritic input to the PFC in this transgenic animal model for PD.
|
31077958 |
2019 |
|
Depressive disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied mice with an analogous mutation (TPH2-R439H), which results in a 60%-80% decrease in levels of 5-HT in the central nervous system and behaviors associated with depression in humans.
|
31071306 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied mice with an analogous mutation (TPH2-R439H), which results in a 60%-80% decrease in levels of 5-HT in the central nervous system and behaviors associated with depression in humans.
|
31071306 |
2019 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We studied mice with an analogous mutation (TPH2-R439H), which results in a 60%-80% decrease in levels of 5-HT in the central nervous system and behaviors associated with depression in humans.
|
31071306 |
2019 |
|
Severe depression
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A variant of TPH2 that encodes the R441H substitution (TPH2-R441H) was identified in individuals with severe depression.
|
31071306 |
2019 |
|
Unipolar Depression
|
0.800 |
Biomarker
|
disease |
BEFREE |
The Interaction of TPH2 and 5-HT2A Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study.
|
31019472 |
2019 |
|
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Interaction of TPH2 and 5-HT2A Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study.
|
31019472 |
2019 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
we studied alterations of cortex and hippocampus in astrocytes and senile plaques by Tph2 conditional knockout (Tph2 CKO) AD mice from 6-10 months of age.
|
30827242 |
2019 |
|
Senile Plaques
|
0.010 |
Biomarker
|
disease |
BEFREE |
we studied alterations of cortex and hippocampus in astrocytes and senile plaques by Tph2 conditional knockout (Tph2 CKO) AD mice from 6-10 months of age.
|
30827242 |
2019 |
|
Unipolar Depression
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Tryptophan hydroxylase-2 polymorphism is associated with white matter integrity in first-episode, medication-naïve major depressive disorder patients.
|
30822678 |
2019 |
|
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Tryptophan hydroxylase-2 polymorphism is associated with white matter integrity in first-episode, medication-naïve major depressive disorder patients.
|
30822678 |
2019 |
|
Caffeine related disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Chronic caffeine exposure for four weeks during adolescence was sufficient to decrease tph2 mRNA expression in the DR measured 28 h after caffeine withdrawal.
|
30579884 |
2019 |